Role of Amyloid Precursor Protein in Astrocytes in Alzheimer´s Disease.

Background Astrocytes are specialized glial cells that when exposed to inflammatory factors go through a process known as reactive astrogliosis. Reactive astrocytes neuropathological feature of Alzheimer’s disease (AD). The etiology AD is often explained by the accumulation β-amyloid peptides, proteolytic product amyloid precursor protein (APP). However, inflammation also plays prominent role in development AD. How astrocytesparticipate pathogenesis remains poorly understood Method To elucidate we exploited different vitro and vivo models investigate Amyloid Precursor setting immune response astrocytes. Result Our results show overexpression APP human cortical induces phenotype, similar found brains patients. These produce significantly increased levels INF-g comparison with control Similar positive correlation between from transgenic traumatic brain injury mice models. Conclusion data indicate activated high APP, which promotes production secretion interferons recapitulates salient features